• ATM Kinase Inhibitor, KU-55933 for cell activation

main product information

 
 

catalog no

1685-5

size

5 mg

price

240 EUR

Other product information

Description

A potent, selective and ATP-competitive inhibitor of ATM Kinase (Ki = 2.2 nM; IC₅₀ = 13 nM). Inhibits DNA-PK, mTOR, PI 3-K, PI 4-K, and ATR at much higher concentrations (IC₅₀ = 2500, 9300, 16600,>100000 and>100000 nM, respectively).

Peptide sequence

N/A

CAS number

587871-26-9

Molecular weight

395.49

Category

Biochemicals

Other name

2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one; KU-55933

Molecular formula

C₂₁H₁₇NO₃S₂

Physical appearance

White solid

Supplied with

N/A

Is this a salt?

No

Is it cell-permeable?

Yes

Purification

≥97% by HPLC

Reconstitute instructions

DMSO (100 mM) and Ethanol (50 mM)

Storage condition

-20°C

Shipping condition

gel pack

Maximum time for storage

24 months

Storage instructions

Protect from air and light

Tissue

cell

Additional description

For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.