main product information
Other product information
Gene info
ATR Antibody: The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.
Gene names
ATR Antibody: ATR, GAPO, TEM8, ATR, Anthrax toxin receptor 1, Tumor endothelial marker 8
Antibodie's label
unlabelled serum
Purity
ATR Antibody is Ion exchange chromatography purified.
Ab raised in
Rabbit
Type
Polyclonal
Immunoglobulin
IgG
Spicific to
Will recognize all three isoforms.
Antigen
ATR antibody was made against a peptide corresponding to 13 amino acids near the center of human ATR.
Immuno application
ELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
Antibody advice
ATR antibody can be used for detection of ATR by Western blot at 0.5 to 2 ug/mL. It will recognize all three isoforms. Antibody can also be used for immunohistochemistry starting at 2 ug/mL. For immunofluorescence start at 10 ug/mL.
Suspention, pH, azide
ATR Antibody is supplied in PBS containing 0.02% sodium azide.
Keep at
ATR antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Works with
Human, Mouse, Rat
Omim nr
16933551
Ncbi nr
NP_444262
Vial with antibody
in solution
Quantity per ml
1 mg/mL
NCBI GENE nr
84168
GENE symbol
ANTXR1
Antigene name
anthrax toxin receptor 1
Source
Homo sapiens
Protein nr
Q9H6X2
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation
anticorps