• anti-ATM Antibody

main product information

 
 

catalog no

3945

size

0.02 mg, 0.1 mg

price

180 EUR

Other product information

Gene info

ATM Antibody: DNA double strand breaks represent a major threat to an organism's genome. Eukaryotic cells have developed mechanisms that sense the presence this damage and initiate suitable responses that can include DNA repair, cell cycle delay, and programmed cell death. The ATM (mutated in Ataxia-Telangiectasia) protein kinase is activated following the formation of DNA double strand breaks, phosphorylating p53 and another kinase CHK2. This initiates a signaling cascade leading to the phosphorylation and inhibition of Cdc25, ultimately preventing cell cycle progression. In some cell types, such as the hemapoietic system, this leads to apoptosis instead of cell cycle arrest. Multiple isoforms of ATM are known to exist.

Gene names

ATM Antibody: AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, Serine-protein kinase ATM, Ataxia telangiectasia mutated, A-T mutated

Antibodie's label

unlabelled serum

Purity

ATM Antibody is affinity chromatography purified via peptide column.

Ab raised in

Rabbit

Type

Polyclonal

Immunoglobulin

IgG

Antigen

ATM antibody was made against a peptide corresponding to 14 amino acids near the carboxy terminus of human ATM.

Immuno application

ELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence

Antibody advice

ATM antibody can be used for detection of ATM by Western blot at 1 - 2 ug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 ug/mL. For immunofluorescence start at 10 ug/mL.

Suspention, pH, azide

ATM Antibody is supplied in PBS containing 0.02% sodium azide.

Keep at

ATM antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Works with

Human

Omim nr

2304971

Ncbi nr

AAB65827

Vial with antibody

in solution

Quantity per ml

1 mg/mL

NCBI GENE nr

472

GENE symbol

ATM

Antigene name

ataxia telangiectasia mutated

Source

Homo sapiens

Protein nr

Q13315

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Properties

If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

French translation

anticorps