![anti-ATM Antibody [3E8]](/images/bondy/dummy.png)
main product information
Other product information
Gene info
ATM-3E8 recognizes full-length ATM, a 370 kDa nuclear phosphoprotein, which is involved in the autosomal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigation. The ATM gene product is a 370 kD nuclear phosphoprotein with C-terminal homology to phosphatidylinositol 3-kinase. ATM is involved in the induction of a DNA damage control pathway. Mutations in the ATM gene cause neuronal degeneration, gonadal abnormalities, and immune deficiencies as part of the hereditary disease ataxia telangiectasia.
Gene names
ATM, A-T mutated, ATA, ATC, ATD, ATE, AT mutated, Ataxia telangiectasia, ATDC, Serine-protein kinase ATM, AT1, Ataxia telangiectasia mutated, TEL1, TELO1
Antibodie's label
unlabelled serum
Purity
Protein G Column
Ab raised in
Mouse
Type
Monoclonal
Monoclonal
[3E8]
Immunoglobulin
IgG1
Antigen
ATM monoclonal antibody was made against recombinant protein expressed in E. coli, amino acids 980 - 1512 of ATM (Human).
Immuno application
Western Blot, immuno-histo-chemistry, immuno precipitation
Antibody advice
ATM antibody can be used in ELISA starting at 1:200 - 1:1000, Western Blot starting at 1:100 - 1:300, immunocytochemistry starting at 1:75, and immunofluorescence starting at 1:25 - 1:50.
Suspention, pH, azide
PBS, pH 7.4. No preservatives added.
Keep at
Store ATM antibody at -20 grades C. As with all antibodies avoid freeze/thaw cycles.
Works with
Human
Omim nr
575773389
Ncbi nr
Q13315
Vial with antibody
in solution
NCBI GENE nr
472
GENE symbol
ATM
Antigene name
ataxia telangiectasia mutated
Source
Homo sapiens
Protein nr
Q13315
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation
anticorps