• anti-ATM (phospho Ser1981) Antibody

main product information

 
 

catalog no

79-156

size

0.1 mg

price

180 EUR

Other product information

Gene info

ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene.

Gene names

AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, APRF, Ataxia telangiectasia mutated homolog, Ataxia telangiectasia mutated, kinase ATM

Antibodie's label

unlabelled serum

Purity

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Ab raised in

Rabbit

Type

Polyclonal

Spicific to

This antibody detects endogenous level of ATM only when phosphorylated at serine 1981.

Antigen

ATM (Phospho-Ser1981) antibody was made against a peptide sequence around phosphorylation site of serine 1981 (E-G-S (p) -Q-S) derived from Human ATM.

Immuno application

Western Blot, immuno-histo-chemistry

Antibody advice

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Suspention, pH, azide

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Keep at

Store antibody at -20 grades C for up to one year.

Works with

Human, Mouse

Omim nr

71902540

Ncbi nr

NP_000042.3

KDa

350 kDa

Vial with antibody

in solution

Quantity per ml

1 mg/mL

NCBI GENE nr

472

GENE symbol

ATM

Antigene name

ataxia telangiectasia mutated

Source

Homo sapiens

Protein nr

Q13315

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Properties

If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

French translation

anticorps